Curcumin, primarily derived from turmeric, and resveratrol, found mainly in grapes, peanuts, and blueberries, are prominent candidates as dietary supplements for promoting healthy longevity. Curcumin may confer health benefits by modulating key biological pathways that reduce oxidative stress, inhibit inflammation and cellular senescence, enhance telomere length, adjust dysregulated nutrient sensing and intercellular communication, and influence epigenetic regulation. In addition to the effects of curcumin, resveratrol is notable for its role in enhancing autophagy and mitochondrial function. Commercial curcumin and resveratrol supplements often display significant variability in their composition, while the concentrations of these compounds in natural food sources are generally much lower than those present in supplemental forms. Although certain regulatory agencies have approved higher safe intake limits due to the low bioavailability of these compounds, definitive guidelines on supplementation dosages for healthy longevity remain lacking. Comprehensive clinical studies that incorporate pharmacokinetic and nutrigenetic analyses are crucial to clarify their potential effects on lifespan extension. In conclusion, until optimal supplementation doses of curcumin and resveratrol for promoting healthy longevity are established, their consumption as part of a balanced dietary model—taking into account the synergistic effects of the food matrix—may offer beneficial outcomes.