The question of the coexistence between extinct fauna and indigenous societies was initiated by Florentino Ameghino (1879, 1880), like many other aspects of South American paleontology, and has been a topic of scientific interest for over a century. After numerous debates, the first reliable records of interaction between indigenous societies and glyptodonts emerged in the mid-20th century. Currently, eight glyptodont specimens are known with evidence of anthropogenic alterations, some of which show the possibility of a very ancient interaction. Radiocarbon dating places the final extinction of glyptodonts around the mid-Holocene.