A design of a removable module for bulk cargo transportation by rail has been proposed to increase the efficiency of railway transportation, A main feature of the removable module is that the end and side walls are made of sandwich panels. This will help to reduce the dynamic loading of the removable module during transportation by rail. Mathematical modelling of the dynamic loading of the removable module when it perceives longitudinal and transverse loads was carried out to substantiate this designed structural solution. It was established that the accelerations acting on the removable module in the longitudinal plane are 9.3% lower than those acting on the structure without sandwich components, and in the transverse plane - by 5.4% in comparison with the standard structure. Moreover, the strength analysis of the removable module under the considered loading modes has been performed. It was established that the maximum stresses in its structure do not exceed the permissible values. The conducted research will contribute to the creation of recommendations for the design of modern structures of detachable transport units (containers, vehicles), as well as for increasing the profitability of bulk cargo transportation by rail.