I once read a little fable called “The Three Princes of Serendipus.” When their Highnesses were traveling, they were continually making discoveries, by accident and sagacity, of things they were not in search of. For instance, one of them discovered that a mule blind in the right eye had lately passed the same road, the grass having been eaten only on the left side, where it was worse than on the right - now do you see serendipity? One of the most remarkable instances of this accidental sagacity (noting that no discovery of what one is in search of can fall under this description) was that of my Lord Shaftesbury. While dining at Lord Chancellor Clarendon’s, he deduced the secret marriage of the Duke of York and Mrs. Hyde simply by observing the extraordinary respect with which the mother treated her daughter at the table. Through this novel Horace Walpole coined the term “serendipity” to mean the casual and unexpected discoveries -the incidental finding- of something unanticipated while actively searching for something else. Over time, this term has come to signify those intuitive and almost magical moments in which valuable knowledge is acquired in specific contexts. Similarly to how Amerigo Vespucci embarked on a long voyage to the Indies only to realize he had discovered an entirely new continent: America, in this chapter, we will undertake a scientific journey throughout the gastrointestinal tract (and beyond), equipped with an ultrasound probe, scientific curiosity, and a measure of patience. Along the way, we identified uncommon pathologies which resulted on value medical findings that may aid in resolving complex clinical cases. Beyond inflammatory bowel disease (IBD), there are numerous other potential causes of abdominal distress, some of wich originating from adjacent tissues.