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This study aimed to evaluate the efficacy of radiomics analysis applied to MRI and PET-CT imaging for the early detection of degenerative changes in SYN120 transgenic mice. These mice, which express human C-terminally truncated \(\alpha \) -synuclein under the control of the rat tyrosine hydroxylase promoter on an \(\alpha \) -synuclein null background, exhibit key neuropathological features characteristic of Parkinson’s disease, including progressive \(\alpha \) -synuclein aggregate deposition and degeneration of nigrostriatal dopaminergic neurons. Radiomics analysis was conducted on SYN120 transgenic mice and \(\alpha \) -synuclein null control mice (OlaHsd) using T2-weighted MRI scans with multiple sequences and PET-CT imaging with three distinct radiotracers: [18F]FDG to assess glucose metabolism, [18F]VC701 to evaluate microglial activation, and [18F]FP-CIT to examine dopamine transporter (DAT) integrity. Imaging was performed at three developmental stages 5, 8, and 10 months to facilitate the identification of early disease biomarkers. Following acquisition, PET and CT images were reconstructed and automatically co-registered. A total of 26 brain regions were delineated using a standardized brain atlas. A three-step radiomics pipeline was applied to extract 93 quantitative features from each defined region. By 10 months of age, the dorsal striatum demonstrated increased metabolic heterogeneity, as indicated by variations in [18F]FDG signal intensity. Whole-brain radiomic analysis further revealed a progressive and diffuse increase in glucose metabolism across multiple brain regions. Notably, alterations in DAT expression were most prominent at 5 months in several regions, including the dorsal striatum, whereas signs of neuroinflammation emerged at later time points.

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Radiomic Analysis of MR and PET Images of Mice to Identify Possible Microstructural Changes Associated with Early Molecular Changes During Nigral Neuron Deafferentation

  • 会议论文

  • 发表日期：

    2026年

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  • Viviana Benfante,
  • Sara Belloli,
  • Gaia Faustini,
  • Arianna Bellucci,
  • Rosa Maria Moresco,
  • Albert Comelli

摘要

This study aimed to evaluate the efficacy of radiomics analysis applied to MRI and PET-CT imaging for the early detection of degenerative changes in SYN120 transgenic mice. These mice, which express human C-terminally truncated \(\alpha \) -synuclein under the control of the rat tyrosine hydroxylase promoter on an \(\alpha \) -synuclein null background, exhibit key neuropathological features characteristic of Parkinson’s disease, including progressive \(\alpha \) -synuclein aggregate deposition and degeneration of nigrostriatal dopaminergic neurons. Radiomics analysis was conducted on SYN120 transgenic mice and \(\alpha \) -synuclein null control mice (OlaHsd) using T2-weighted MRI scans with multiple sequences and PET-CT imaging with three distinct radiotracers: [18F]FDG to assess glucose metabolism, [18F]VC701 to evaluate microglial activation, and [18F]FP-CIT to examine dopamine transporter (DAT) integrity. Imaging was performed at three developmental stages 5, 8, and 10 months to facilitate the identification of early disease biomarkers. Following acquisition, PET and CT images were reconstructed and automatically co-registered. A total of 26 brain regions were delineated using a standardized brain atlas. A three-step radiomics pipeline was applied to extract 93 quantitative features from each defined region. By 10 months of age, the dorsal striatum demonstrated increased metabolic heterogeneity, as indicated by variations in [18F]FDG signal intensity. Whole-brain radiomic analysis further revealed a progressive and diffuse increase in glucose metabolism across multiple brain regions. Notably, alterations in DAT expression were most prominent at 5 months in several regions, including the dorsal striatum, whereas signs of neuroinflammation emerged at later time points.