Non-communicable diseases represent a silent pandemic, accounting for 74% of global deaths annually. In India, 29.8 million patients with cancer are projected by 2025, with the northeastern states showing the highest vulnerability, where 57,131 patients are anticipated. Government actions appear constrained by political and financial compulsions, leading to insufficient efforts to address risk factors like tobacco and alcohol consumption. Stakeholders’ roles in disease prevention remain unclear, while the COVID-19 pandemic highlighted the inadequacies in prevention strategies and stakeholder engagement. Approximately 70% of COVID-19-related deaths involved non-communicable diseases and comorbidities. Individual lifestyle choices significantly contribute to non-communicable disease prevalence, and government policies inadvertently enable risky behaviors. Environmental conditions further exacerbate disease prevalence, while the socioeconomic burden of non-communicable diseases heavily impacts health systems and society. Moreover, 50% of risk factors are modifiable. This study explores the burden of non-communicable diseases, particularly cancer, in high-risk northeastern states of India and evaluates stakeholder roles in prevention. Published reports from research institutes, ministries, and departments were reviewed and analyzed within a policy framework to assess disease burden and clarify stakeholder responsibilities. The authors propose a policy model for stakeholders, beyond healthcare actors, to enhance cancer and non-communicable disease prevention and control in the region.