Psychological factors such as self-efficacy, optimism, positive emotions, and cognitive reappraisal directly affect resilience. These factors interact with the neural circuitry and stress response system. Genetic, epigenetic, and environmental factors (e.g., resources, family, and community support) influence the neural circuitry and stress response system, thereby enhancing resilience. Therapeutic and preventive interventions such as stress management, cognitive behavioral therapy, prayer, and psychopharmacotherapy can enhance resilience by targeting biopsychosocial factors. Spiritual power—that is, the ability to find purpose and meaning in life amid trauma—is associated with resilience. Beyond the personal level, greater unity and collaboration are needed to combat shared challenges such as pandemics, climate change, and pollution, thereby promoting social and global resilience.