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This chapter explores the applicationApplications of the DEMDiscrete Element Method (DEM) in pharmaceutical manufacturingPharmaceutical manufacturing processes. It highlights how DEM provides critical particle-level insights into unit operations crucial for medicinal product quality. Detailed applications in millingMilling, blendingBlending, granulationGranulation, tablettingTabletting and coatingCoating processes are reviewed. The chapter demonstrates DEM’s vital role in optimizing equipment design, process parametersProcess parameters and ensuring final product efficacy and consistency, ultimately accelerating process development and scale-up.

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Applications to Pharmaceutical Manufacturing

  • 章节

  • 发表日期：

    2026年

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  • Ramesh K. Agarwal,
  • Yali Shao

摘要

This chapter explores the applicationApplications of the DEMDiscrete Element Method (DEM) in pharmaceutical manufacturingPharmaceutical manufacturing processes. It highlights how DEM provides critical particle-level insights into unit operations crucial for medicinal product quality. Detailed applications in millingMilling, blendingBlending, granulationGranulation, tablettingTabletting and coatingCoating processes are reviewed. The chapter demonstrates DEM’s vital role in optimizing equipment design, process parametersProcess parameters and ensuring final product efficacy and consistency, ultimately accelerating process development and scale-up.