The aim of this article is to describe the importance of acquiring attitudes and skills related to systems thinking and the role of design thinking in addressing sustainability issues. Understanding the concepts of systems thinking and planning sustainable processes through different activities and tools is the basis for designing for sustainability. Embracing sustainability values and addressing the complexity of sustainability is also part of the GreenComp reference framework for European sustainability competences as a driver for learning for environmental sustainability [1]. The Minifactory laboratory concept allows learners to visualise, evaluate, analyse, and experiment with systems thinking techniques in the design of a more sustainable and holistic production process. Systems thinking is one of the key skills in product life cycle assessment (LCA). LCA is a systems-based tool and deals with systems from a much broader and deeper perspective [2]. Such aspects require the adoption of systems thinking, which in turn is defined as the ability to see the parts of larger mechanisms, to recognise patterns and to reorganise these interactions in a more efficient and effective way. Digitisation and 3D technology have great potential in the fashion industry. It is not only about speeding up the production process, but also about digitising product development and the production process, ensuring that personalised production (mass customisation) is possible in the industry. Acquiring new knowledge and applying new skills is a necessary step towards reducing the environmental impact of the clothing and textile industry and making it more sustainable.