Posthepatectomy liver failure (PHLF) is recognized as the leading cause of mortality after major hepatectomy [1]. Despite recent advances to improve outcomes, the incidence of PHLF can reach 30% [2] and its severity can range from a simple disorder in biological liver function to a state of multisystemic failure with refractory ascites, jaundice, renal and respiratory failure, hemodynamic instability, and encephalopathy. In major hepatectomies, PHLF accounts for approximately 40% of the 90-day postoperative mortality [3]. Liver transplantation, which is rarely available in this setting, remains the only definitive treatment for patients with persistent PHLF.