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Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has evolved from an experimental approach into a consolidated tool in advanced liver surgery. This chapter reviews the historical development, future liver remnant (FLR) hypertrophy response, patient selection, technical variants, and oncological outcomes of ALPPS. While early reports highlighted significant morbidity and mortality, refinements in technique and strict patient selection criteria have markedly improved safety. Current evidence demonstrates that ALPPS provides rapid and effective FLR hypertrophy, expands resectability, and offers encouraging long-term outcomes in well-selected patients, particularly those with colorectal liver metastases.

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ALPPS: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy

  • 章节

  • 发表日期：

    2026年

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  • Victoria Ardiles,
  • Fernando A. Alvarez,
  • Eduardo de Santibañes

摘要

Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has evolved from an experimental approach into a consolidated tool in advanced liver surgery. This chapter reviews the historical development, future liver remnant (FLR) hypertrophy response, patient selection, technical variants, and oncological outcomes of ALPPS. While early reports highlighted significant morbidity and mortality, refinements in technique and strict patient selection criteria have markedly improved safety. Current evidence demonstrates that ALPPS provides rapid and effective FLR hypertrophy, expands resectability, and offers encouraging long-term outcomes in well-selected patients, particularly those with colorectal liver metastases.