Hypertensive disorders of pregnancy (HDP) are becoming a more and more common way to refer to disorders of pregnancy where high blood pressure is a downstream effect of very different diseases. If we look at traditional listings of risk factors, almost any known disease is added, from undernutrition to obesity and from diabetes to immune disorders. In this multifactorial syndrome, we still find the Greek word “preeclampsia” (προεκλαμψία: something that occurs before the sudden occurrence of something, example “lightening” or “fits”), one of the last surviving esoteric Greek or Latin words used by doctors to hide the true ignorance on the origin of diseases, such as “dropsy” (υδρωπικία ιατρική: accumulation of abnormal amounts of lymph fluid in the tissues and cavities), when cardiac, renal, or liver diseases where beyond reach, or even diabetes (σιφόνι: passing though; a large discharge “of urine”) mellitus (honeyed -urine), when diabetes was still parted according to the age of patients and not according to its pathophysiology. Now, even preeclampsia is no longer defined by hypertension and proteinuria but by hypertension and organ damage. Maternal hemodynamics have been proven to be evidence after evidence that this diagnostic approach, added to robust immunologic knowledge, is of paramount importance in sorting out different phenotypes of HDP to guide diagnosis and personalized therapy.