For many decades, placental insufficiency was considered the main actor in obstetrical complications such as fetal growth restriction and hypertension in pregnancy. Thus, clinical and research interests were mainly concentrated on the feto-placental unit and maternal arterial pressure. In fact, there is no doubt that in these complications there is an inadequate trophoblastic invasion, but the question is whether the mother is marly a “container” of the feto-placental unit and passively suffers these changes, or there might be a more active role of the maternal cardiovascular system and hemodynamic changes in the development of obstetrical complications.