The chapter provides a comprehensive, practical exploration into strategic decision-making for space economy ventures, bridging cutting-edge theory with real-world application. It introduces three actionable frameworks: Start, Evolve, and Walk Away, each tailored to critical stages of a company’s journey, founding a new venture, transforming established enterprises, and making disciplined exit decisions from high-risk projects. The chapter features global case studies, India’s ISRO (Start), Italy’s Sitael (Evolve), and the USA’s SpaceX (Walk Away). The cases demonstrate how leading space organisations operationalise disruptive innovation, organisational agility, sustainability, regulatory compliance, and financial strategy. Readers benefit from systematic tables summarising advantages, drawbacks, and decision factors for each framework, along with practical checklists and real-world project examples, including ESA BIC, UK Space Accelerator, and NASA SBIR. From ISRO’s cost-efficient missions to Sitael’s collaborative constellation platforms and SpaceX’s evidence-based pivots, this chapter distils empirical insights for entrepreneurs, executives, and policymakers aiming to navigate the complexities of space entrepreneurship. The chapter is essential reading for stakeholders seeking not just to launch or transform in the space sector, but to achieve long-term resilience, sustainability, and competitive edge through structured, research-backed strategies.