As global tipping points in climate change approach, the nexus of climate change, migration, and health demands urgent and concerted action. This book explores the complexities of this nexus, applying the International Organization of Migration’s broad definition of migration, which includes voluntary, involuntary, and immobile populations. The escalating impact of climate change on human mobility—both through sudden and slow-onset events—has profound implications for health and health systems, especially in terms of infectious diseases, non-communicable diseases (NCDs), and mental health. While much of the current discourse frames these challenges around human rights and loss and damage, the interplay between climate-induced migration and health is increasingly recognized, though remains under-researched. This edited volume adopts a transdisciplinary and international perspective to address these gaps, leveraging the research framework developed by the CliMigHealth network. It presents a series of chapters that examine elements within the climate-migration-health nexus through a regional integration lens, exploring how regional dynamics, governance structures, and collaborative efforts can shape effective responses. The book highlights the importance of adopting transdisciplinary research approaches and frameworks for designing such responses. Through contributions from diverse regions and research fields, it offers insights into (health) risk reduction, climate change mitigation and adaptation strategies, loss and damage mechanisms, and the role of health diplomacy in responding to the nexus. Ultimately, the volume aims to guide future research and policy, fostering resilience, health equity, and sustainable development across borders.