Infusion therapy has emerged as a valuable modality in pain management, particularly for patients with refractory conditions who have failed conventional treatments. This chapter outlines the billing and coding strategies necessary to ensure reimbursement and compliance when delivering intravenous therapies. Given the frequent off-label use of various infusion agents, clinicians must navigate complex payer requirements, including appropriate CPT, HCPCS, and ICD-10 codes, and rigorous documentation standards. The chapter provides coding maps for common therapies, discusses payer appeal strategies, and emphasizes risk mitigation approaches to avoid claim denials. Pain specialists can ensure financial sustainability while optimizing patient care by aligning clinical innovation with accurate billing practices.