Benzodiazepines are in a class of psychoactive drugs that involve a chemical structure consisting of the fusion of a benzene and diazepine rings. They enhance the neurotransmitter gamma-aminobutyric acid (GABA) and can treat a variety of conditions ranging from anxiety to spasms. Continuous systemic benzodiazepine administration, specifically midazolam, has shown benefit in alleviating neuropathic pain and preventing thermal hyperalgesia.