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Broadband NIRS (bNIRS) is an extension of fNIRS that provides the same assessment of oxygenation biomarkers along with a valuable marker for oxygen metabolism at a cellular level, the oxidation state of cytochrome-c-oxidase (oxCCO). bNIRS implements many (100s) wavelengths in the NIR spectrum to address this and provide insight into tissue energetics. To supply these many wavelengths of light, broadband sources are required, and spectrometers are employed to distinguish power per wavelength. Current multi-channel bNIRS instruments are bulky and only semi-portable due to technological limitations. We propose a design for a bNIRS device that has been miniaturised to allow for portable use. This design leverages the innovations in photonic devices that have created a new line of SMD-type micro-spectrometers and broadband NIR high-power LEDs. This first-of-its-kind device, referred to as microCYRIL (after its two predecessors CYRIL and miniCYRIL), has been developed for oxygenation and metabolism measurements with dual channel operation. To validate functionality, concentration changes in oxygenated (HbO2) and deoxygenated (HHb) haemoglobin and oxCCO were successfully tracked during a cuff-induced brachial arterial occlusion.

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A Portable Broadband Near-Infrared Spectroscopy Device for In Vivo Oxygenation and Metabolism Measurements

  • 会议论文

  • 发表日期：

    2026年

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  • Musa Talati,
  • Frédéric Lange,
  • Dimitrios Airantzis,
  • Danial Chitnis,
  • Temisan Ilukwe,
  • Darshana Gopal,
  • Paola Pinti,
  • Niccole Ranaei-Zamani,
  • Olayinka Kowobari,
  • Sarah Johnson,
  • Olivia Newth,
  • Sara Hillman,
  • Dimitrios Siassakos,
  • Anna L. David,
  • Subhabrata Mitra,
  • Ilias Tachtsidis

摘要

Broadband NIRS (bNIRS) is an extension of fNIRS that provides the same assessment of oxygenation biomarkers along with a valuable marker for oxygen metabolism at a cellular level, the oxidation state of cytochrome-c-oxidase (oxCCO). bNIRS implements many (100s) wavelengths in the NIR spectrum to address this and provide insight into tissue energetics. To supply these many wavelengths of light, broadband sources are required, and spectrometers are employed to distinguish power per wavelength. Current multi-channel bNIRS instruments are bulky and only semi-portable due to technological limitations. We propose a design for a bNIRS device that has been miniaturised to allow for portable use. This design leverages the innovations in photonic devices that have created a new line of SMD-type micro-spectrometers and broadband NIR high-power LEDs. This first-of-its-kind device, referred to as microCYRIL (after its two predecessors CYRIL and miniCYRIL), has been developed for oxygenation and metabolism measurements with dual channel operation. To validate functionality, concentration changes in oxygenated (HbO2) and deoxygenated (HHb) haemoglobin and oxCCO were successfully tracked during a cuff-induced brachial arterial occlusion.