This chapter advances the Sensible Design framework by applying it to three core sensory dimensions: Visual/Lighting, Acoustics, and Spatial Orientation and Flow. It challenges the implicit visual bias in conventional architectural practice and highlights the limitations of Universal Design (UD) when implemented without explicit sensory criteria. The proposed framework offers a flexible yet structured model that aligns with UD principles, while addressing diverse sensory profiles, preferences, and priorities. By integrating insights from neuroscience, neurodiversity, disability studies, and inclusive design, the framework introduces sensory-specific, threshold-responsive design strategies that enhance both accessibility and well-being, explicitly mapping them to UD principles and differentiated sensory thresholds (baseline, low, and high). Special emphasis is placed on visual ergonomics, acoustic zoning, and spatial flow—including wayfinding, spatial sequencing, and transitions—all of which are essential for supporting sensory modulation and autonomy. By identifying points of overlap between sensory needs and inclusive spatial strategies, this chapter illustrates how Sensible Design elevates environments from merely usable to deeply legible and welcoming. The result is a practical, scalable approach to design that affirms neurodiversity, mitigates sensory overload, and fosters belonging across diverse users. The chapter also presents real-world examples and illustrations and provides practical design prompts applicable across diverse environments.