Plants play a vital role in sustaining life on Earth. Beyond forming the foundation of terrestrial ecosystems, they provide oxygen, contribute to the food chain, and exhibit a wide range of morphological and biochemical diversity. Among their various ecological functions, certain plant species possess allelopathic properties, which allow them to inhibit the growth of surrounding vegetation through the release of specific chemical compounds. These properties offer promising alternatives to synthetic herbicides, which contribute to environmental pollution and herbicide resistance. This review explores endemic plant species from the state of Coahuila, Mexico, with potential allelopathic activity, highlighting their secondary metabolites and their application as natural, biodegradable herbicides.