The increasing bacterial resistance has been driven by the ineffectiveness of treatments and the excessive use of antibiotics, which has led to the search for new therapies. This chapter explores the main clinically important bacteria that exhibit resistance and their acquisition mechanisms, as well as the various multidisciplinary solutions proposed for this conflict, such as biotechnology. This ranges from developing antibiotics using techniques for obtaining bioactive compounds, based on ancestral medicine, to using genetic tools. The potential of nanotechnology in administering antibacterial agents with high biocompatibility is also being evaluated. All this promotes sustainable research, taking advantage of the traditional knowledge of our resources.

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Biotechnology in the Fight Against Bacterial Resistance

  • Ainara Castillo-Manzanares,
  • María D. Estrada-Flores,
  • Roberto Arredondo-Valdés,
  • Valeria González-Urquizo,
  • Julia C. Anguiano-Cabello,
  • José L. Martínez-Hernández,
  • Marco A. Tucuch-Pérez

摘要

The increasing bacterial resistance has been driven by the ineffectiveness of treatments and the excessive use of antibiotics, which has led to the search for new therapies. This chapter explores the main clinically important bacteria that exhibit resistance and their acquisition mechanisms, as well as the various multidisciplinary solutions proposed for this conflict, such as biotechnology. This ranges from developing antibiotics using techniques for obtaining bioactive compounds, based on ancestral medicine, to using genetic tools. The potential of nanotechnology in administering antibacterial agents with high biocompatibility is also being evaluated. All this promotes sustainable research, taking advantage of the traditional knowledge of our resources.