A 46-year-old female presented to the emergency department with symptoms of headache, dizziness, and nausea following smoke inhalation from a house fire caused by a phone explosion. She was a non-smoker with no significant past medical history. Initial evaluation revealed a carboxyhemoglobin (COHb) level of 14%, with normal vital signs, neurological examination, and imaging studies. The patient was treated with 100% high-flow oxygen via a non-rebreather mask, resulting in symptomatic improvement and a reduction in COHb levels to 5% within six hours. She was discharged after 24 hours with complete resolution of symptoms. A follow-up neurological evaluation one week later was unremarkable. Carbon monoxide (CO) poisoning is a potentially life-threatening condition that can occur due to smoke inhalation. Early diagnosis and prompt treatment are critical in preventing complications. This case highlights the importance of timely recognition and management of CO poisoning through oxygen therapy. Despite significant exposure, early intervention led to full recovery without neurological complications.