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The interplay between epilepsy and anxiety is complex. Anxiety is associated with fear of seizures, but is also a constituent of epilepsy itself. Treating one could help to improve the other. Both disorders involve dysregulations of the hypothalamic pituitary adrenal axis. Anti-seizure medicines may be well suited to also treat anxiety, namely benzodiazepines. 1,5 benzodiazepines, such as clobazam, are structured differently from those typically prescribed, and may be better tolerated as a result. This is a case of a patient who was socially withdrawn and avoidant, but also had seizures and marked academic disengagement. After clobazam treatment, there was significant improvement in seizure control, anxiety, and social confidence.

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Anxious about Epilepsy: Simultaneous Treatment of Co-occurring Anxiety and Epilepsy

  • 章节

  • 发表日期：

    2026年

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  • D. Dilara Ertenu,
  • Cynthia Bonner,
  • Patricia Shepley,
  • Jay A. Salpekar

摘要

The interplay between epilepsy and anxiety is complex. Anxiety is associated with fear of seizures, but is also a constituent of epilepsy itself. Treating one could help to improve the other. Both disorders involve dysregulations of the hypothalamic pituitary adrenal axis. Anti-seizure medicines may be well suited to also treat anxiety, namely benzodiazepines. 1,5 benzodiazepines, such as clobazam, are structured differently from those typically prescribed, and may be better tolerated as a result. This is a case of a patient who was socially withdrawn and avoidant, but also had seizures and marked academic disengagement. After clobazam treatment, there was significant improvement in seizure control, anxiety, and social confidence.