Cerebral palsy (CP) is the most common childhood-onset motor disorder. While frequently associated with prematurity and periventricular leukomalacia, our understanding of the role of genetics in the development of cerebral palsy is rapidly growing, with potential implications on treatment. Neuropsychiatric co-occurring conditions are common in people with CP. The reason for this association is likely multifactorial, including shared neurobiological mechanisms as well as interwoven biopsychosocial risks. Motor and neuropsychiatric symptoms have bidirectional influences, and diagnostic overshadowing is common. Accurate diagnosis is further complicated when there are co-occurring communication disorders or intellectual disability. Finally, neuroactive medications can have synergistic or opposing effects on these domains. Coordination across disciplines optimizes diagnostic and treatment strategies.