Carbon Capture and Storage (CCS) is crucial for reducing CO₂ emissions, and depleted oil and gas fields offer ideal storage sites due to their well-understood geology and proven trapping capacity. This study outlines key geological screening criteria for CCS site selection, focusing on reservoir quality, caprock integrity, structural stability, and long-term risks. Effective storage requires evaluating reservoir porosity, permeability, and depth to ensure optimal CO₂ injectivity and capacity. A reliable caprock (e.g., shale or salt layers) is essential to prevent leakage, while structural assessments must address fault stability and fracture risks. CO₂ trapping mechanisms—structural, solubility, residual, and mineral—vary by geology and must be optimized for secure storage. Geomechanical (pressure changes) and geochemical (rock-fluid interactions) factors further influence long-term containment. Monitoring via seismic surveys and gas analysis helps track CO₂ migration and detect leaks. Despite their advantages, challenges remain in predicting long-term storage behavior. Advanced modeling and pilot projects are needed to refine risk assessments. By integrating reservoir characterization, structural analysis, and geochemical evaluations, CCS in depleted hydrocarbon reservoirs can safely contribute to global decarbonization, leveraging existing data and infrastructure for efficient implementation.