Background: The purpose of this research is to study the bioeconomy of the renowned Ecological Economist and father of the European Bioeconomy Nicholas Georgescu-Roegen, which is linked to the epistemological currents in Latin America and the Caribbean (LAC) to explain the emergence of a new economic paradigm called “Latin Bioeconomy” that includes the theory of energy value proposed by Georgescu-Roegen, whose physical basis of the thermodynamic theory and the second Law of Entropy is enriched with three new concepts called Bioculture, Bioterritoriality, and Bioinformation. Methodology: The research was of an exploratory documentary using VosViews bibliometric tools to explain how one production model is developed from another. The open innovation method is used that articulates the convergence of ancestral and modern knowledge, translated into bioculture, which coincides with the bibliographic review of authors identified as epistemologists of the South, who disagree with the absolutist models of orthodox economies. The deductive method is also followed to deduce conclusions that go from the general to the particular. Results and discussion: A space is created for Latin American political philosophies of Welfare such as Vivir Bien/Vivir Bien, to give social content to orthodox economics, complementing it, making it multidisciplinary, and expanding its theoretical-methodological coverage, to solve problems that currently affect humanity. The discovery is defined as an epistemology of Latin American sentiment that provides answers to the European energy theory of value proposed by the Romanian Georgescu-Roegen, also adding the concepts of bioculture, bioterritoriality, and bioinformation.