Our work aims to enhance the performance of manufacturing systems by proactively integrating Lean functional requirements into the design phase within an I5.0 framework. This approach minimizes the need for Lean adjustments during the operational phase of future manufacturing systems. It represents a shift in mindset from a reactive problem-solving approach to a proactive strategy that embeds Lean principles from the design phase. Additionally, this integration aligns with key I5.0 principles, including sustainability, resilience, and human-centricity. By examining the synergies between Lean, Industry 4.0 (I4.0), and Industry 5.0 (I5.0) principles, this article demonstrates how Lean has inherently aligned with the fundamental principles of I5.0 even before its official emergence. By integrating the technological advancements of I5.0 with classic Lean concepts that support its core values, our objective is to develop the Lean 5.0 paradigm integrating digital advancements with human-centric, sustainable, and resilient manufacturing practices.