The impact of chamfer corners for a tall building under the interference effect was studied using Large Eddy Simulation (LES), which was solved using the Lattice Boltzmann Method (LBM). Two buildings, identical in size, were spaced at 1.5 times their width. Six chamfer rates between 0% and 25% were applied on the principal building and tested under different wind incidence angles. The Aerodynamic Interference Factors (AIF) of base moment coefficients for along wind, across wind, and torsional components were evaluated to quantify the interference effect. It was found that increasing chamfer rates generally lower the AIF, with a 15% chamfer rate providing the optimal reduction across most conditions. However, a 20% chamfer rate produced decreased performance and even adverse effects, particularly at a 135° wind direction, where it increased the root-mean-square (RMS) across wind base moment coefficient, C’ML. Furthermore, chamfer modifications were less effective against along wind forces, particularly when the shielding effect from the interference building is dominant. This study provides insights into the effectiveness of chamfering as an aerodynamic modification in urban settings to enhance structural stability and reduce wind-induced loads.