This chapter examines Iamblichus’ Response to Porphyry as a manifesto calling to esoteric religious action the intellectual elite of Late Antiquity. Rather than merely defending theurgy against philosophical criticism, the text represents a deliberate attempt to resignify pagan religion by establishing a new ‘orthopraxy’ centered on direct divine communication through epiphanic experiences. The chapter situates Iamblichus within his socio-historical context as a prominent figure of Syrian intellectual culture who positioned himself as an authority on religious matters by adopting the literary persona of an Egyptian priest, Abammon. Through this Egyptian connection, Iamblichus asserted the primacy of ancient hieratic practices while simultaneously aligning them with Platonic philosophy. Central to Iamblichus’ religious vision was the role of epiphany—divine manifestations that validated religious rituals and established authentic communication with the divine. By privileging these experiences, Iamblichus sought to shift religious authority from traditional temple priests to philosopher-theurgists. The chapter argues that Iamblichus’ project was not merely philosophical speculation but a ‘call to action’ directed at the intellectual elite, aiming to revitalise traditional religion through the integration of philosophical principles and theurgic practices during a period of religious uncertainty.