Imaging plays a critical role in the management of metastatic disease to bone. It is used for lesion detection, biopsy and surgical planning, soft tissue extension assessment, pathologic fracture (or impending fracture) assessment, and treatment response monitoring. All diagnostic imaging modalities, except for ultrasound, are routinely used in the management of osseous metastases. MRI remains the gold-standard modality because of its high sensitivity and tissue contrast. In this chapter, we review the appearance of metastatic lesions of bone across relevant imaging modalities.