This paper presents part of an experimental program aiming to investigate the fatigue behavior of full-scale prestressed hollowcore slabs strengthened with externally bonded prestressed CFRP plates using a novel field-applicable wedge anchorage system. Three slabs were tested under fatigue cyclic loading; one slab served as a control, while two others were strengthened with externally bonded CFRP plates prestressed to 60% of their ultimate tensile strength and subjected to different load ranges. The results showed that the prestressed CFRP strengthening system enhanced the fatigue life of the strengthened slabs. The CFRP plate anchorage system demonstrated reliable performance, with no signs of premature failure throughout testing, demonstrating its efficiency for practical applications in structures subject to cyclic loading such as bridges and parking decks.