The modern workforce is grappling with several critical issues, and leaders have a significant role to play in addressing them. One major area of focus is neurodiversity, which refers to the natural differences in how people think, learn, and solve problems. This concept is transforming how organizations think about talent by highlighting the unique strengths individuals with conditions like autism, ADHD, and dyslexia can bring to the workplace. These strengths, however, often require tailored support systems to fully flourish (Austin & Pisano, 2017). Alongside this, organizations are struggling with a global talent shortage, as the demand for skilled workers continues to outpace supply. This gap in the labor market is compounded by increasing levels of workplace stress, which negatively affect productivity, employee well-being, and organizational resilience (World Health Organization, 2022). This chapter explores these three intertwined challenges and provides practical strategies for leaders to create inclusive workplaces where all employees can thrive (Fig. 2.1).