Humans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in most high-density cattle-raising regions. This article shows an in silico investigation of the relation between BCoV and the current SARS-CoV-2 pandemic. Brazil was used as a model for the analysis of the impact of bovine populations on the prevalence of COVID-19 in people. Throughout the country, there were areas in which COVID-19 prevalence was disproportionally low, with regards to transport infrastructure. Areas with high cattle density had lower COVID-19 prevalence in these low-risk areas. Also, we determined HLA recognition and human lymphocyte reactivity to BCoV epitopes using bioinformatics resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for human B and T lymphocytes. These data are a preliminary indication that cross-protection is possibly being induced by human exposure to cattle.