This research focuses on analyzing the economic-fiscal performance of the real estate, business and rental activities sector in Ecuador. The central purpose of this study was to establish the differences between the main activities of the sector, such as: real estate activities, rental activity of machinery and equipment without operators and personal effects and household goods, computer activity and activities related, research and development and other business activities. For this purpose, the monthly INA-R database was used, corresponding to the period 2011–2021. Two non-parametric tests were applied: the Kruskal Wallis test, then the Man Whitney U test, both tests allowed us to determine the level of relationship between the main activities. Variations in economic-fiscal performance and profitability between different activities were identified. In conclusion, the analysis of the economic-fiscal performance of this sector provides a comprehensive vision of the evolution and significant contribution of the most efficient or profitable activities to the country’s economy.