In recent years, there is a need and interest in developing modern constructions that are responding to climate challenges following sustainable development and practices. The construction engineering sector is responsible for 40–50% greenhouse gas emissions, so that, given the current requirements in the field, the materials produced using energy-intensive technologies are changed in favor of materials from sustainable and environmentally friendly sources. Wood and wood derived products such as glued laminated timber (GLT) and cross laminated timber (CLT) elements have known a strong expansion in the past years as a better alternative for conventional building materials due to the mechanical properties that follow sustainable standards that make it competitive with classic building materials. The current study focuses on the behavior of the layer component in the timber elements when variations of humidity are directly applied focusing on the moisture distribution and identification of the most critical area of water accumulation. Also, the effects of the interaction between the two types of materials CLT and GLT in an assembly is considered when analyzing the transfer of lateral forces by improvement of structural efficiency through optimal interaction between elements and climate changes. The influence of moisture distribution in the layers is also analyzed and observed. Excessive moisture content and continuous changes in the external environment can produce severe structural damages in buildings. This is why, continuous monitoring of the evolution of moisture content in a variable environment is essential. The results of the study analyses different layer configurations in the multi-layered elements with their reaction to climatic changes and the results that appear in the elements in relation with the fiber saturation point, degradation and possible structural damage.