This chapter explores the importance of culturally adapting telepsychotherapy to meet the needs of diverse populations in an increasingly globalized world. As migration increases, individuals often face mental health challenges when adjusting to new environments, including isolation and exacerbation of pre-existing conditions. Telepsychotherapy, which delivers psychological services through digital platforms, offers a scalable and effective way to provide mental health care across cultural boundaries. However, to be effective, these interventions must be adapted to align with the cultural contexts of the target population. The chapter introduces key concepts such as cultural competence and cultural adaptation, emphasizing the need for modifications that go beyond language translation to address deeper cultural values, beliefs, and practices. Several frameworks for cultural adaptation are discussed, with examples illustrating how these can be applied to telepsychotherapy. The authors also highlight challenges in maintaining the efficacy of interventions while ensuring cultural relevance. Through a critical review of current research and practical strategies, the chapter underscores the potential of culturally adapted telepsychotherapy to increase accessibility, engagement, and therapeutic outcomes, while also addressing the limitations and areas for future development in this emerging field.