Stroke remains a leading cause of morbidity and mortality worldwide, necessitating the development of specialized stroke units to optimize patient outcomes through timely intervention, standardized care, and multidisciplinary collaboration. This chapter provides a comprehensive overview of stroke unit organization, detailing the structure and function of acute stroke units, stroke centers, and neurocritical care units. It explores the role of infrastructure, advanced medical equipment, and multidisciplinary teams in facilitating rapid diagnosis, acute intervention, and rehabilitation. The importance of stroke unit certification and quality improvement initiatives is emphasized, highlighting the impact of evidence-based protocols, performance metrics, and regulatory frameworks on stroke care outcomes. By embracing innovation and maintaining high standards of care, stroke units will continue to serve as specialized centers dedicated to improving survival, neurological recovery, and long-term patient well-being.