This chapter presents summaries of research about the impact of cultural differences in emotion expression and regulation in clinical settings. Therapeutic success in emotionally overwhelming situations depends on the therapist’s ability to empathize and culturally attune to the client. Cultural differences in emotional expression and regulation can complicate therapy, especially in cross-cultural contexts. Western-based clinical psychology often requires adaptation for non-Western clients, such as Asian Americans, who may prefer structured approaches like CBT and mindfulness due to cultural norms around emotional suppression. Missteps occur when therapists apply Western standards without considering cultural values, potentially harming the therapeutic alliance. Studies emphasize the importance of cultural sensitivity, active listening, and co-constructing meaning to avoid misunderstandings. Sociocultural attunement goes beyond awareness, requiring therapists to reflect on how societal and cultural contexts shape emotional experiences. In humanitarian settings, urgency can hinder cultural alignment, making client feedback essential to avoid harm. Overall, effective cross-cultural therapy demands core counseling skills, cultural humility, and a dynamic, respectful approach to each client’s unique sociocultural identity. Disclaimer: The summaries in this chapter were generated from Springer Nature publications using generative AI. The content was curated by the editor to meet Springer Nature publication standards. As the constituted sentences are machine-created, they may not fully reflect the body of the work, so we strongly advise that the original content is read and cited.