Shakespeare and Early Modern Madness offers fresh, cutting-edge reinterpretations of William Shakespeare’s preoccupation, throughout his works, with madness and mental health. In addition to investigating the ubiquity of mental health tropes in Shakespearean theatre, the collection branches out into explorations of madness motifs in the drama of Shakespeare’s contemporaries Ben Jonson and Christopher Marlowe. The collection overall is energized by the belief that madness is a variable concept, affiliated in the Renaissance with mental states as different as demonic possession, melancholic dreams, ecstasy and rapture, rage and fury, excessive grief, and aesthetic pleasure. The essays further demonstrate that madness in early modern drama can be approached through a diverse array of critical perspectives, including gender studies, critical race methodologies, and film theory, as well as psychological and psychiatric sciences. In particular, this volume showcases how concepts from disability studies and mad studies can illuminate our understanding of mental health in early modern theatre. The collection concludes with a section on activism and pedagogy that asks how we can use early modern plays to promote the inclusion of students and scholars with lived experience of neurodivergence.