This article explores enhancing manufacturing system performance by integrating Lean requirements into the design phase within the Industry 5.0 context. The goal is to reduce the need for Lean interventions during the operational phase of future manufacturing systems. Rather than addressing inefficiencies reactively, we propose to proactively integrate Lean from the beginning, shifting the focus from curative problem-solving to prevention. Our approach comprising three main facets: “Design a Sustainable Lean Manufacturing System”, “Design a Resilient Lean Manufacturing System”, and “Design a Human-Centric Lean Manufacturing System”. While integrating Lean and Industry 5.0 requirements during the design phase is important, the process of combining multiple requirements and their associated parameters can lead to a complex system that may sometimes contain contradictions. In this article, we present the Lean 5.0 Parameter Integration Matrix (L5.0PIM) methodology, and highlight its significance in resolving contradictions that may arise during the design of Lean 5.0 manufacturing systems. Additionally, we present an application of L5.0PIM in an Additive Manufacturing System. Instead of treating technical and physical contradictions separately, the problem-solving phase in our methodology uses a new approach to ensure that both types of contradictions are resolved within a single design step.