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Establishment of cervical cancer (CC) involves multiple steps such as binding of human papillomavirus (HPV) late (L) proteins L1 and L2 with key factors such as heparin sulphate proteoglycans (HSPG), epidermal growth factor receptor (EGFR), furin, and annexin A2 on the surface of epithelial cells in the transition zone of cervix. Upon internalization, the HPV early (E) proteins E5, E6, and E7 get integrated into host chromosomes and interfere with the actions of pRb and p53. Bromodomain-containing protein 4 (BRD4) is key in mediating the integration of viral proteins with host chromosomes. When these viral proteins are produced, they are processed into peptides and presented on the surface of infected cells, which invites cytotoxic T cells to ensue apoptosis. HPV downregulates the major histocompatibility complex (MHC)-I expression to minimize its presentation to immune cells and increases the programmed death (PD)-L1 expression, to exhaust the immune cells through PD-1. This chapter is an attempt to understand the microRNA (miRNA) signature of these critical molecules and to explore the possibilities of utilizing these miRNAs as markers in predicting the stages of diseases. The present chapter also explores the therapeutic potential of miRNA mimics and antagonists.

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MicroRNAs Involved in the Regulation of Critical Genes and Their Relevance in the Theragnostics of HPV-Driven Cervical Cancer

  • 章节

  • 发表日期：

    2026年

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  • Sneha Krishnamoorthy,
  • Vidya Balasubramanian,
  • Jayapradha Gnanagurusamy,
  • Rajalakshmi Sabanayagam,
  • Ilangovan Ramachandran,
  • Sridhar Muthusami

摘要

Establishment of cervical cancer (CC) involves multiple steps such as binding of human papillomavirus (HPV) late (L) proteins L1 and L2 with key factors such as heparin sulphate proteoglycans (HSPG), epidermal growth factor receptor (EGFR), furin, and annexin A2 on the surface of epithelial cells in the transition zone of cervix. Upon internalization, the HPV early (E) proteins E5, E6, and E7 get integrated into host chromosomes and interfere with the actions of pRb and p53. Bromodomain-containing protein 4 (BRD4) is key in mediating the integration of viral proteins with host chromosomes. When these viral proteins are produced, they are processed into peptides and presented on the surface of infected cells, which invites cytotoxic T cells to ensue apoptosis. HPV downregulates the major histocompatibility complex (MHC)-I expression to minimize its presentation to immune cells and increases the programmed death (PD)-L1 expression, to exhaust the immune cells through PD-1. This chapter is an attempt to understand the microRNA (miRNA) signature of these critical molecules and to explore the possibilities of utilizing these miRNAs as markers in predicting the stages of diseases. The present chapter also explores the therapeutic potential of miRNA mimics and antagonists.