Flood risk zoning is an important part of the comprehensive risk census of global natural disasters. This paper focuses on the Weihe River in China and conducts research using hydrometeorological and socioeconomic data in accordance with relevant technical requirements and specifications. During the zoning process, natural characteristics, socioeconomic factors, and historical flood situations are comprehensively considered. With the help of the ArcGIS software and DEM files, the region is divided into main river flood control areas, mountain flood threat areas and local flood threat areas, and then finely divided in combination with factors such as topography and geomorphology. The HEC-RAS software is used to build a flood routing model, and the risk element index value sets of each unit are obtained. Based on these indicators, the comprehensive risk degree is calculated, and the study area is divided into four risk zones: extremely high, high, medium, and low. Finally, the flood risk map is compiled, providing a scientific basis for flood prevention and disaster reduction.