Neurodegenerative diseases represent significant challenges globally in healthcare affecting millions with no conclusive cure. These disorders include Alzheimer’s, Parkinson’s, and Huntington’s, among others, characterized commonly by neuronal loss, nervous system dysfunction, and progressive degeneration of the nervous system. The most challenging parts of neurodegenerative diseases with conventional therapeutic strategies are specific drug delivery and treating them in the presence of the blood-brain barrier (BBB). Advancements in metal bio-nanocomposites have proved to be potential tools to address these challenges in recent years and have shown great promise in neurodegenerative diseases. These advanced materials can potentially transform the treatment and understanding of neurodegenerative diseases by combining the functional advantages of metal nanoparticles with biocompatible matrices due to their unique structure and properties, offering new avenues for therapeutic interventions and diagnostic tools. This chapter aims to extensively study the latest advancements in metal bio-nanocomposites and their applications in addressing neurodegenerative diseases; particularly targeting Alzheimer’s, Parkinson’s, Huntington’s, and related neurodegenerative disorders. This chapter discusses different mechanisms by which new materials can alleviate oxidative stress, suppress neurotoxic protein aggregation, and promote neuronal regeneration in the domain of neuroscience and disease management.