This study explores the role of knowledge-based systems (KBSs) in addressing the growing health needs of African populations. Healthcare specialists are in high demand, but their numbers are very limited in sub-Saharan Africa (SSA). Despite being predominated by paramedical personnel (over 90% of medical staff), SSA health systems are characterized by poorly distributed, large medical centers, a lack of continuing training, and inadequate resources for maintenance and knowledge updating. Establishing KBSs, particularly expert systems, could address these difficulties by continuously assisting health professionals and improving health structures while transforming them into effective learning organizations. Implementing KBSs can greatly benefit the sustainable development of SSA healthcare by enhancing the skills of health professionals. The @san project was initiated to make current knowledge available and useful for daily tasks via an expert system model. The results obtained show that implementing such intelligent solutions involves simplifying access to knowledge, promoting information circulation, and addressing the needs of a homogeneous group of users, among others. This study evaluates the developed prototype by briefly outlining the current pressing needs of SSA health systems and highlighting the requirements for targeted digital support technology for future research.