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Ewing's sarcoma (ES) is an aggressive pediatric malignancy characterized by poor prognosis and limited therapeutic options, particularly in the metastatic phase. Multiple diagnostic approaches are being used to cure children from this disease. Recently, microRNAs, specifically let-7a has emerged as a critical tumor suppressor whose dysregulation contributes to ES pathogenesis through the modulation of key oncogenic pathways. In the current study, nucleotide sequences of both let-7a and EWSR1 were accessed from miRbase and NCBI databases, respectively. Moreover, their three-dimensional structures were predicted using computational approaches. Molecular docking experiments were utilized to study their interaction behavior. The generated heatmap graph shows the significance of hsa-let-7a in cellular signaling pathways associated with Ewing's Sarcoma. Our computational results suggest that hsa-let-7a can potentially be a significant factor in the development of miRNA-based therapeutics for the treatment of ES.

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Computational Insights into the Role of Let-7a MicroRNAs in Ewing's Sarcoma

  • 会议论文

  • 发表日期：

    2026年

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  • Saba Shahzadi,
  • Mubashir Hassan,
  • Andrzej Kloczkowski

摘要

Ewing's sarcoma (ES) is an aggressive pediatric malignancy characterized by poor prognosis and limited therapeutic options, particularly in the metastatic phase. Multiple diagnostic approaches are being used to cure children from this disease. Recently, microRNAs, specifically let-7a has emerged as a critical tumor suppressor whose dysregulation contributes to ES pathogenesis through the modulation of key oncogenic pathways. In the current study, nucleotide sequences of both let-7a and EWSR1 were accessed from miRbase and NCBI databases, respectively. Moreover, their three-dimensional structures were predicted using computational approaches. Molecular docking experiments were utilized to study their interaction behavior. The generated heatmap graph shows the significance of hsa-let-7a in cellular signaling pathways associated with Ewing's Sarcoma. Our computational results suggest that hsa-let-7a can potentially be a significant factor in the development of miRNA-based therapeutics for the treatment of ES.