The ventilation system is the fundamental system for ensuring safe production in mines. As the central core of mines, it plays an important role in air exchange, dust removal, and heat reduction. The reasonable layout of mine ventilation system is an important guarantee for achieving safe production in mines. How to optimize the layout of mine ventilation system is an important issue in mine construction, and it is also an important foundation for ensuring mine safety and reducing the frequency of disasters. With the continuous development of mineral resources, the mining depth of Linglong Gold Mine has exceeded 1 km, while facing a complex mining environment with multiple veins and high mining depth. Taking the ventilation system of Dongfeng Mining as an example, the increasing depth of the mine and the complexity of tunnel extension have led to low accuracy in measuring and monitoring ventilation parameters, weak matching between ventilation power and ventilation network, weak automatic adjustment ability of underground equipment to achieve on-demand air supply, poor deep cooling effect, and serious dust and oil fume pollution, which urgently need to be solved.