Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, poses significant threats to ecosystems and human health. While its toxicological effects on animals are well-documented, molecular mechanisms underlying plant responses to BPA stress remain poorly understood. This review synthesizes current knowledge on BPA sources, environmental distribution, and dose-dependent effects on plant physiology, emphasizing epigenetic regulation as a key adaptive mechanism. We highlight research gaps in plant detoxification pathways and propose leveraging advanced epigenetic technologies (e.g., CUT&Tag, spatial multi-omics) to decode stress memory mechanisms. Our analysis provides critical insights for developing phytoremediation strategies against BPA contamination.