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The accurate monitoring of DNA damage in radiotherapy patients is essential for evaluating the effects of radiation exposure and the effectiveness of treatment. The comet assay, a widely used technique to detect DNA strand breaks at the single-cell level, is recognized for its sensitivity and adaptability in radiation biodosimetry. However, enhancing the throughput, sensitivity, and automation of the assay is vital for clinical applications. The innovations presented in material selection, sensor design, and automation mark a significant step forward in the use of the comet assay for radiation exposure monitoring, paving the way for personalized medicine approaches in radiotherapy and beyond. This study aims to discuss material recommendations for biosensors using advanced materials to improve the functionality of the DNA comet assay for radiation exposure monitoring.

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Materials for Biosensor Designation of DNA Comet Assay for Radiotherapy Patients’ Exposure Monitoring

  • 会议论文

  • 发表日期：

    2025年

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  • Cem Gök,
  • Arzum Işıtan,
  • Massimo Bersani,
  • Ahmet Koluman

摘要

The accurate monitoring of DNA damage in radiotherapy patients is essential for evaluating the effects of radiation exposure and the effectiveness of treatment. The comet assay, a widely used technique to detect DNA strand breaks at the single-cell level, is recognized for its sensitivity and adaptability in radiation biodosimetry. However, enhancing the throughput, sensitivity, and automation of the assay is vital for clinical applications. The innovations presented in material selection, sensor design, and automation mark a significant step forward in the use of the comet assay for radiation exposure monitoring, paving the way for personalized medicine approaches in radiotherapy and beyond. This study aims to discuss material recommendations for biosensors using advanced materials to improve the functionality of the DNA comet assay for radiation exposure monitoring.