Society 5.0 is important as it allows businesses and industries to provide proper resolutions for society to ensure social stability aggressively. Society 5.0 is more advanced than Society 4.5 with advanced technology, providing robots and smart machines working processes in business. The major strategies of society are human-centric, resilience, sustainability, etc. E-commerce takes the advances of society 5.0 in the creation of higher business profit growth by delivering the goods and services, that afford greater personalization for customers and improve the quality of goods and services by the feedback facilities. The help of this automation creates a service-based model in business, where customers can focus on adding value for the end-user. This chapter mainly covered Society 5.0 and e-commerce, major discussion advantages of Society 5.0 in e-commerce, E-commerce business model, digital transformation Society 5.0 information society, workflow of factories, Society 5.0 policies and strategies, value chain management, etc. Human-centered computing facilities enhance the e-commerce scope in developing countries, these countries take crucial advantage of e-commerce and small-scale enterprises having a share of international trade with the large scope they also compete in the global market.