In order to improve the intelligent development of e-commerce, this paper puts forward an e-commerce business model based on cloud computing, which uses the basic model of supply chain to build the core business process, constructs the management model of enterprise supply chain concretely, and then uses the computer platform and related technologies of enterprise itself to continuously improve and enhance the service process of enterprise, rationally allocate enterprise resources, structure each functional part of the model, and continuously optimize the operation effect of e-commerce cloud service platform. It can be seen that the business model of e-commerce cloud service platform proposed in this paper performs well in data processing, procurement efficiency, production efficiency, sales efficiency, logistics efficiency and after-sales evaluation, which will promote the intelligent development of subsequent e-commerce. The experimental analysis shows that the business model of e-commerce cloud service platform proposed in this paper performs well in data processing, procurement efficiency, production efficiency, sales efficiency, logistics efficiency and after-sales evaluation.